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Zyclara Warnings and Precautions

Before using Zyclara, tell your healthcare provider if you have a weakened or overactive immune system or if you have any other skin problems. Safety precautions associated with Zyclara also include warnings of potentially severe skin reactions or flu-like symptoms. Also, this drug may not be safe for use in people taking certain medications, or for women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Zyclara® (imiquimod cream) if you have:
  • A weakened immune system due to any cause
  • An overactive immune system
  • A sunburn
  • Any other skin problems
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Undergoing treatment for actinic keratosis with surgery or other medications
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
In addition, tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Zyclara

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • Zyclara usually causes skin reactions. These reactions vary from a little redness to very severe problems like painful ulceration of the skin. If your reaction is severe enough, you will have to stop using Zyclara, either temporarily or permanently.
  • This medication may worsen existing skin conditions, particularly chronic graft versus host disease of the skin. If you have chronic graft versus host disease, you may not be a good candidate for Zyclara treatment.
  • Do not use Zyclara on skin that is not fully healed from surgery or other treatments, including other medications.
  • In some cases, flu-like symptoms occur before or along with skin reactions to Zyclara. These symptoms can include things such as:
    • Fatigue
    • Nausea
    • Fever
    • General ill feeling
    • Joint pain
    • Muscle pain
    • Chills.
Sometimes, these symptoms are bothersome enough to require people to either temporarily or permanently stop using the drug. It can take up to a month after treatment for these side effects to go away.
  • Avoid sun exposure during treatment with Zyclara; this includes both natural sunlight and sun lamps. Wear sunscreen and protective clothing if sun exposure cannot be avoided.
  • This product should be used with caution by people with conditions involving an overactive immune system, as the drug probably works by activating the immune system. This means that Zyclara could, at least theoretically, make such conditions worse.
  • This product is a pregnancy Category C medicine, meaning it might not be safe for use during pregnancy, although the full risks are currently unknown (see Zyclara and Pregnancy for more information).
  • It is unknown if Zyclara passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before using this medicine (see Zyclara and Breastfeeding).

Zyclara Medication Information

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