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What is Promethazine Prescribed For?

Promethazine hydrochloride (Phenergan®) is a sedating antihistamine that belongs to a group of medications known as phenothiazines.
Promethazine is prescribed for several different uses. The medication is often used for:
  • Treating the following conditions:
    • Perennial (year-round) or seasonal allergies
    • Nonallergic nasal symptoms due to irritants
    • "Allergy eyes" (allergic conjunctivitis)
    • Hives
    • Allergic reactions to blood or plasma transfusions
    • Severe, anaphylactic allergic reactions (when used with other medications)
  • Treating or preventing nausea and vomiting related to surgery and general anesthesia (see Phenergan for Nausea)
  • Treating or preventing motion sickness
  • Causing sedation in the following situations:
    • Before or after surgery
    • During labor
    • In situations when mild anxiety relief and light sleep is desired.
Healthcare providers may also occasionally prescribe promethazine for off-label uses, such as for treating morning sickness, nausea and vomiting related to gastrointestinal illness (like the "stomach flu"), or coughing.
(Click What Is Promethazine Used For? for more information on what promethazine is often prescribed for, how this medication works, and whether it is used in children.)
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