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Precautions and Warnings With Metronidazole Gel

Make sure your healthcare provider knows if you have any allergies or a history of low blood cell counts before starting rosacea treatment with metronidazole gel. Other precautions and warnings for safely using this medicated skin gel include possible risks of drug interactions and safety concerns for women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to using metronidazole gel (Metrogel®) if you:
  • Have any allergies, including to medications, foods, dyes, or preservatives
  • Have a history of low blood cell counts
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Metronidazole Gel Precautions and Warnings

Some warnings and precautions to be aware of prior to using this rosacea medicine include the following:
  • Metronidazole gel is for skin use only. Do not swallow it, and make sure to keep it out of the eyes. This skin gel is not intended for vaginal use; a different product called Metrogel-Vaginal® is approved for vaginal use.
  • In rare cases, some people may develop peripheral neuropathy due to metronidazole gel. Contact your healthcare provider if you develop any signs of this problem, such as burning, tingling, or pricking in the extremities (the hands, lower legs, and feet).
  • Make sure your healthcare provider knows if you have a history of low blood counts, such as low white blood cells, low platelets, or anemia. Although it is probably quite unlikely, metronidazole gel could make these problems worse.
  • Some people experience contact dermatitis (a skin reaction) with this medication. If your rosacea is not improving and seems to be getting worse, let your healthcare provider know.
  • The active ingredient in metronidazole gel passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before using this skin gel (see Metrogel and Breastfeeding).
  • Metronidazole gel is a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Metrogel and Pregnancy for more information).

Metronidazole Gel Information

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