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Live vaccines are immunizations that contain live viruses or bacteria. If you receive a live vaccine while taking ustekinumab, you might become infected with the virus or bacteria from the vaccine. Also, ustekinumab can make live vaccines less effective. You should not receive live vaccinations while taking it.
One particular vaccine (the BCG vaccine) should be avoided for one year before and one year after treatment with ustekinumab.
Other Immune-Suppressing Medications
Ustekinumab has not been studied in combination with other immunosuppressants. At this time, it is unknown if such combinations are safe or effective.
Ustekinumab may indirectly affect how the liver handles theophylline. Therefore, your healthcare provider should monitor you closely and adjust your theophylline dosage as necessary. Your healthcare provider may find it useful to monitor the level of theophylline in your blood.
Ustekinumab may indirectly affect how the liver handles warfarin. Therefore, your healthcare provider should monitor you closely and adjust your warfarin dosage as necessary.