Skin Home > Picato Warnings and Precautions

Before beginning treatment with Picato, your healthcare provider will need to know if you have a sunburn or any other skin problems. Safety precautions associated with Picato also include warnings of potentially severe skin reactions. In addition, this drug may not be safe for use in people who are being treated for actinic keratosis with surgery or other medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Picato® (ingenol mebutate) if you have:
  • A sunburn
  • Any other skin problems
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Being treated for actinic keratosis with surgery or other medications
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
In addition, tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Picato

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • Picato usually causes skin reactions. These reactions can vary from a little redness to severe problems like painful ulcerations of the skin. Plan for the likely possibility that you will have a skin reaction. For instance, you may want to avoid using this medication right before a situation in which you will need to look your best.
  • Do not use Picato on skin that is not fully healed from sunburn, surgery, or other treatments, including other medications.
  • This product is a pregnancy Category C medicine, meaning it might not be safe to use during pregnancy, although the full risks are currently unknown (see Picato and Pregnancy for more information).
  • It is unknown if Picato passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider or your child's healthcare provider before using this medicine (see Picato and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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