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Dosage of OnabotulinumtoxinA for Eyelid Spasms

The recommended onabotulinumtoxinA dose for eyelid spasms (known medically as blepharospasm) is 0.05 to 0.1 mL per injection site (for a total of 1.25 to 2.5 units) into certain muscles that control the eyelids.

Dosing for Misaligned Eyes

The recommended dose of onabotulinumtoxinA for misaligned eyes (known medically as strabismus) is 0.05 to 0.15 mL per muscle. Special techniques must be used to ensure injection into the proper site. Often, this is done with a special needle that measures electrical signals from the muscle. Your healthcare provider may give you anesthetic eye drops a few minutes before your injection.

OnabotulinumtoxinA Dose for Severe Sweating

For treating severe underarm sweating, the standard dosing guidelines call for 50 units of onabotulinumtoxinA per underarm, given in several small injections. Before the injections, your healthcare provider may do a painless procedure that stains the area of increased sweating in order to target the therapy to the appropriate area.

OnabotulinumtoxinA Dosage for Chronic Migraines

For preventing chronic migraine headaches, the standard recommended dose is 155 units of onabotulinumtoxinA, given in 31 small injections in specific muscles of the face, head, and neck. Treatment should be repeated every 12 weeks.

OnabotulinumtoxinA Dosage for Upper Limb Spasticity

For treating upper limb spasticity, the recommended onabotulinumtoxinA dosage is highly variable, ranging from 75 to 360 units per treatment session. The dosage will depend on the size and number of muscles, the severity of the spasticity, whether or not you have muscle weakness, and how you have responded to onabotulinumtoxinA in the past. Treatment sessions can be repeated as soon as the effects wear off (but no sooner than every 12 weeks).
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Last reviewed by: Kristi Monson, PharmD;
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