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If you have certain types of T-cell lymphoma, a healthcare provider may prescribe Istodax. This drug is specifically designed for people who have already had at least one form of lymphoma treatment. It comes as an intravenous injection that is administered by a healthcare provider. Most people will develop some type of side effect, such as nausea, fatigue, or infections.

What Is Istodax?

Istodax® (romidepsin) is a prescription medication approved to treat certain types of T-cell lymphoma, a cancer that begins in the cells of the immune system. Specifically, the medication is approved to treat peripheral T-cell lymphoma and cutaneous T-cell lymphoma. It is designed for use in people who have already received at least one previous type of treatment for their lymphoma.
(Click Istodax Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Istodax is made by Ben Venue Laboratories, Inc., for Celgene Corporation.

How Does Istodax Work?

Istodax belongs to a class of medicines known as histone deacetylase (HDAC) inhibitors. The exact way it works to treat T-cell lymphoma is unknown. The medication interferes with important proteins involved in gene expression -- the process by which the information contained in genes is interpreted. It may stop cancer cells from reproducing and cause cell death.

When and How to Receive It

Some general considerations to keep in mind during treatment with Istodax include the following:
  • Istodax is given as a slow injection into a vein (an intravenous, or IV, infusion) over a four-hour period.
  • The injection is administered by a healthcare provider in a healthcare setting, such as a hospital or clinic.
  • Doses are usually given about a week apart for three doses, followed by a short break, for a 28-day treatment cycle.
  • The medication should be inspected before use and should not be given if it contains particles or is discolored.
  • For Istodax to work properly, it must be used as prescribed. It is important to keep your appointment to receive your dose.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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