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People who have malignant melanoma or Hodgkin's disease may benefit from dacarbazine. This chemotherapy drug comes as an injection that is given into a vein once daily for 5 to 10 days, followed by a break in treatment. Side effects are common and may include nausea, vomiting, and loss of appetite.

What Is Dacarbazine?

Dacarbazine (DTIC-Dome®) is a prescription chemotherapy medication. It is approved to treat malignant melanoma (a type of skin cancer) that has spread to other areas of the body (metastasized). It is also approved for use in combination with other medications to treat Hodgkin's disease (also known as Hodgkin's lymphoma). Dacarbazine is also sometimes referred to simply as DTIC.
(Click What Is Dacarbazine Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, dacarbazine can cause side effects. As with other chemotherapy medicines, the side effects can be significant and potentially serious. In fact, most people will experience some type of dacarbazine side effect during treatment. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Common side effects of dacarbazine include but are not limited to:
  • Nausea
  • Vomiting
  • Loss of appetite.
(Click Dacarbazine Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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