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Diflorasone Diacetate Warnings and Precautions

If your healthcare provider recommends diflorasone diacetate, tell him or her if you have any allergies or if you are taking any other medications. Safety precautions with diflorasone diacetate also include warnings of complications this drug may cause when used for extended periods, such as diabetes or Cushing's syndrome. Also, women who are pregnant or breastfeeding may not be able to use it.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using diflorasone diacetate if you:
  • Are breastfeeding
  • Are pregnant or thinking of becoming pregnant
  • Have any allergies, including to food, dyes, or preservatives.
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Diflorasone Diacetate

Some warnings and precautions to be aware of when using this medication include the following:
  • Like all steroids, diflorasone diacetate may slow down the growth rate of children and teenagers. Contact your child's healthcare provider if you are concerned about this. In general, children may be more susceptible to side effects of steroids. Close monitoring is necessary for any child receiving long-term steroids. Diflorasone diacetate is not specifically approved for use in children.
  • Diflorasone diacetate can cause serious steroid side effects, such as Cushing's syndrome or diabetes. Although this is more likely to occur with oral or injected steroids, it is still possible with topical steroids. The more you apply and the longer you use the drug, the more likely these problems are to occur. Covering the treatment area with a dressing may also increase the risk.
  • If you use this medication for an extended period, be sure to watch for any signs of Cushing's syndrome (a group of symptoms caused by prolonged exposure to steroids), such as:
    • A rounded face
    • Unusual body fat distribution (more fat in the trunk, face, and neck, and less fat in the arms and legs)
    • High blood sugar. 
Let your healthcare provider know if you think you have signs of this problem. 
  • Diflorasone diacetate can suppress the body's ability to make natural steroids. Usually, this happens when large doses are used over a long period, which is not recommended. In such circumstances, this drug should be stopped slowly to give your body a chance to begin making natural steroids again. If this is not feasible, you might need to be given an oral steroid for a while, after which you will be slowly weaned off it.
  • If you develop a skin infection while using this product, you will need to be treated with appropriate antibiotics or antifungal medications. If the infection does not clear up, you may need to stop using diflorasone diacetate.
  • Diflorasone diacetate can potentially react with a few other medications (see Diflorasone Diacetate Drug Interactions).
  • This product is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Diflorasone Diacetate and Pregnancy).
  • It is unknown if diflorasone diacetate passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Diflorasone Diacetate and Breastfeeding).

Diflorasone Diacetate Drug Information

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