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Denileukin Diftitox

Denileukin diftitox is a chemotherapy drug licensed to treat a certain type of cutaneous T-cell lymphoma. It works by binding to a certain protein on the cancer cells, causing them to die. It is given as an intravenous injection for five days in a row, once every three weeks. Most people using this drug will experience some type of side effect, such as vomiting, diarrhea, or chills.

What Is Denileukin Diftitox?

Denileukin diftitox (Ontak®) is a prescription medication approved to treat certain types of cutaneous T-cell lymphoma, a cancer of the immune system that affects the skin. It is reserved for people whose condition has not improved or has returned after other types of treatment.
(Click What Is Denileukin Diftitox Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, denileukin diftitox can cause side effects, some of which can be quite significant. In fact, the majority of people who use this drug will experience some type of reaction. Talk with your healthcare provider about ways to prevent or treat certain side effects of this medicine.
Common side effects of denileukin diftitox include but are not limited to:
  • Fever
  • Nausea
  • Fatigue
  • Chills or shaking
  • Vomiting
  • Diarrhea.
(Click Denileukin Diftitox Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
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Denileukin Diftitox Drug Information

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