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Clobex Warnings and Precautions

Because Clobex is not suitable for certain people, make sure your healthcare provider knows if you have any allergies or if you are pregnant or breastfeeding. The safety precautions for Clobex also include warnings of potential complications this drug might cause, such as diabetes or Cushing's syndrome. Also, using this medicine for extended periods can prevent the body from making its own natural steroids.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Clobex® (clobetasol propionate) if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Have any allergies, including to food, dyes, or preservatives.
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Warnings and Precautions With Clobex

Some warnings and precautions to be aware of with this drug include the following:
  • Clobex is a highly potent steroid. It is essential to follow your healthcare provider's dosing instructions carefully. Overuse can lead to serious side effects.
  • Clobex is a steroid and can cause serious side effects, such as Cushing's syndrome or diabetes. Although this is more likely to occur with oral or injected steroids, it is still possible with topical steroids such as Clobex. The more you apply and the longer you use the drug, the more likely these problems are to occur. Covering the medication with a dressing, which is not recommended, may also increase the risk.
  • This medication should not be used for more than two to four weeks at a time, depending on the severity of your condition and the particular form of Clobex. Although the drug is effective, it should not be used on a long-term basis.
  • If you use this medication for an extended period, which is not recommended, be sure to watch for any signs of Cushing's syndrome, a group of symptoms caused by prolonged exposure to steroids. Symptoms include:
    • A rounded face
    • Unusual body fat distribution (more fat in the trunk, face, and neck, and less fat in the arms and legs)
    • High blood sugar.
Let your healthcare provider know if you think you have signs of this problem.
  • Clobex can suppress the body's ability to make natural steroids. Usually, this happens when large doses are used over a long period, which is not recommended. In such circumstances, the drug should be stopped slowly to give your body a chance to begin making natural steroids again. If this is not feasible, you might need to be given an oral steroid for a while, after which you will be slowly weaned from this.
  • Like all steroids, Clobex may slow down the growth rate of children and teenagers. Contact your child's healthcare provider if you are concerned about a slow growth rate in your child. In general, children may be more susceptible to side effects of steroids. Close monitoring is necessary for any child receiving long-term steroids.
  • Clobex can suppress the immune system, perhaps leading to infections or other problems.
  • Clobex can potentially react with a few other medications (see Clobex Drug Interactions).
  • This product is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Clobex and Pregnancy).
  • It is unknown if Clobex passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Clobex and Breastfeeding).

Clobex Drug Information

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