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Basic Information on Clindamycin/Benzoyl Peroxide

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Eczema
  • Sunburned, windburned, or otherwise irritated skin
  • Sensitivity to the sun or spend a lot of time in the sun
  • Colitis
  • Crohn's disease
  • Ever had inflammation of the colon from taking antibiotics (antibiotic-associated colitis)
  • Plans to have surgery with general anesthesia
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Clindamycin/Benzoyl Peroxide to learn more, including information on who should not take the drug.)

How Does It Work?

As mentioned, clindamycin/benzoyl peroxide is a combination of two active medicines: benzoyl peroxide and clindamycin. These two medicines work in different ways to stop Propionibacterium acnes (P. acnes), the bacteria that contribute to acne.
Clindamycin binds to bacterial ribosomes (the parts of cells that make proteins). This prevents the bacteria from making proteins, which are essential for the bacteria to grow and multiply.
Benzoyl peroxide is thought to work by releasing oxygen into the skin's pores. Because P. acnes is an anaerobe, which means it lives without oxygen, the oxygen kills the bacteria. Benzoyl peroxide also helps soften and peel away the outer layer of the skin, which may open up clogged pores and help improve the skin's appearance.

Clindamycin/Benzoyl Peroxide Information

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