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Clinical Effects

In clinical studies, Cinryze was shown to reduce swelling and the number of painful attacks that occurred in people with HAE. In these studies, people were given Cinryze for 12 weeks and a placebo (an injection with no active ingredients) for 12 weeks.
People in the study had an average of 6.1 attacks during the 12 weeks of Cinryze treatment, compared with an average of 12.7 attacks during the 12 weeks of using the placebo. People also had 66 percent fewer days of swelling when taking Cinryze.

When and How to Use It

Some general considerations to keep in mind during treatment with Cinryze include the following:
  • Cinryze comes as a powder that is dissolved in Sterile Water for Injection to form a liquid. It is given as an injection into a vein (an intravenous, or IV, injection) every three or four days.
  • The injections may be given by your healthcare provider or may be self-injected.
  • If you will be self-administering this medication, your healthcare provider will teach you exactly how to use it. Make sure you completely understand these instructions before giving yourself injections.
  • Each Cinryze dose is injected slowly over 10 minutes.
  • You should wash your hands before preparing your dose, and make sure to work on a clean surface to prevent contaminating the medicine with germs.
  • Inspect Cinryze vials after mixing, and only use the medication if it is colorless to slightly blue and free from particles.  
  • For the medication to work properly, it must be used as prescribed.

Dosing Information

There is only one standard dose of Cinryze, regardless of your age. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Cinryze Dosage for more information.)

Cinryze Medication Information

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