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Precautions and Warnings With Brimonidine Gel

Brimonidine gel can make some conditions worse, such as depression, heart disease, and low blood pressure. Other warnings to be aware of with brimonidine gel include safety precautions for those who have certain allergies and people who are taking certain medications. Talk to your healthcare provider about your medical history and any medications and supplements you are taking before using this rosacea medicine.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using brimonidine gel (Mirvaso®) if you have:
  • Depression
  • Raynaud's syndrome
  • Chest pain or other heart problems
  • Ever had a stroke or mini-stroke
  • Orthostatic hypotension (low blood pressure when changing positions)
  • Thromboangiitis obliterans (a condition that causes multiple clots in the hands and feet)
  • Scleroderma
  • Sjögren's syndrome
  • Have any allergies, including to medications, foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant  
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Brimonidine Gel Precautions and Warnings

Some warnings and precautions to be aware of prior to using brimonidine gel include the following:
  • Brimonidine gel should be used with caution in people with depression, heart disease, Raynaud's disease, a history of a stroke, low blood pressure, or thromboangiitis obliterans, as there is a small chance that brimonidine gel could make them worse. However, many people with such conditions can safely use brimonidine gel without any problems whatsoever. You may need extra monitoring, just to be safe.
  • This medication is for skin use only. Do not swallow it, and make sure to keep it out of the eyes. Brimonidine gel can cause dangerous problems if taken by mouth.
  • Some people experience skin redness and flushing, which is exactly the opposite of what you want when treating rosacea. If this effect goes away quickly and you are left with skin that is less red, you may be able to live with this as a mildly bothersome side effect. However, if brimonidine gel makes your redness worse for hours, it's probably not a good option for you.  
  • Brimonidine gel is a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Mirvaso and Pregnancy).
  • It is unknown if brimonidine gel passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider or your child's healthcare provider before using this medicine (see Mirvaso and Breastfeeding).

Brimonidine Gel Information

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