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Understanding How Alefacept Works and Safety Considerations

What Should I Tell My Healthcare Provider Before Starting Treatment?

You should talk with your healthcare provider prior to taking alefacept if you have:
  • A history of tuberculosis or hepatitis B
  • Any current infection
  • Infections that come and go, such as cold sores
  • Any disease that affects the immune system, such as diabetes, cancer, HIV, or AIDS
  • A history of any type of cancer
  • Plans to receive vaccinations
  • Liver disease, such as hepatitis, liver failure, or cirrhosis
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medications, vitamins, and herbal supplements.
(Click Precautions and Warnings With Alefacept to learn more, including information on who should not take the drug.)

How Does Alefacept Work?

Alefacept is a fusion protein. In other words, it is a part of an antibody that has been fused to a special protein. The medication is thought to work by binding to T-cells (a certain type of immune system cell), preventing them from becoming activated and reducing their number. Overactive T-cells are believed to play a large role in causing the symptoms of plaque psoriasis.

Alefacept Drug Information

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