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Drug Interactions With Adapalene/Benzoyl Peroxide

It is not expected that adapalene/benzoyl peroxide will cause serious interactions with other drugs. However, this medication comes in the form of a skin gel and may increase your risk of reactions when used with other skin products, including medicated soaps, astringents, and cosmetics. Some of these skin reactions may include redness, dryness, stinging, and burning.

An Overview of Adapalene/Benzoyl Peroxide Interactions

Adapalene/benzoyl peroxide (Epiduo®) is a prescription medication used to treat acne in people 12 years old and older. It is a combination of two acne medications -- adapalene (Differin®) and benzoyl peroxide. Adapalene/benzoyl peroxide comes in the form of a gel that is applied to the affected skin areas. It is unlikely to interact with other medications.
Adapalene/benzoyl peroxide can irritate the skin when it is first used (see Side Effects of Adapalene/Benzoyl Peroxide). Therefore, be cautious when using adapalene/benzoyl peroxide with other skin products that are potentially irritating to the skin. Some of these other potentially irritating topical products may include:
  • Medicated soaps and cleansers
  • Astringents
  • Skin care products with a high alcohol concentration
  • Skin care products that can dry the skin.
Using these products with adapalene/benzoyl peroxide may increase the risk for skin reactions, such as redness, dryness, stinging, and burning. If you must apply other skin products that may be potentially irritating, ask your healthcare provider about whether these products can be used with adapalene/benzoyl peroxide, or if you must temporarily stop using them.
It is a good idea to develop a complete skin care plan with your healthcare provider, making sure to discuss all possible skin products you use, including sunscreen, cleansers, moisturizes, and cosmetics.

Adapalene/Benzoyl Peroxide Drug Information

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