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Common Reactions to Vorinostat

Common Side Effects

Vorinostat has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what problems occurred and how often they appeared.
In these studies, the most common vorinostat side effects included:
  • Fatigue -- in up to 52.3 percent of people
  • Diarrhea -- up to 52.3 percent
  • Nausea -- up to 40.7 percent
  • Abnormal taste in the mouth -- up to 27.9 percent
  • Low platelet counts (which could cause abnormal bleeding or bruising) -- up to 25.6 percent
  • Decreased appetite -- up to 24.4 percent
  • Weight loss -- up to 20.9 percent
  • Muscle spasms -- up to 19.8 percent
  • Hair loss -- up to 18.6 percent.
Other common reactions, occurring in 10.5 percent to 16.3 percent of people, included:
  • Dry mouth
  • Increase in blood creatinine (found using a blood test)
  • Chills
  • Vomiting
  • Constipation
  • Dizziness
  • Low red blood cells (anemia)
  • Swelling of the arms, hands, legs, ankles, or feet
  • Headache
  • Itching
  • Cough
  • Upper respiratory infections, such as the common cold
  • Fever.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using vorinostat or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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