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Rheumatrex Uses

There are several uses for the prescription drug Rheumatrex. For example, a healthcare provider may recommend the medication for certain types of cancer, rheumatoid arthritis, juvenile rheumatoid arthritis, or psoriasis. It's important to note that this drug can cause serious side effects, so Rheumatrex should only be used in cases where other medications or treatments have been tried first.

What Is Rheumatrex Used For?

Rheumatrex® (methotrexate) is a prescription medication used for several unrelated purposes. It is approved to treat the following conditions:
Because Rheumatrex can cause very serious side effects, it is important to make sure other, less toxic medications have been tried first (if appropriate). Your healthcare provider will need to monitor you carefully, with frequent blood tests to check your kidney function, liver function, and blood cell counts. Chest x-rays to check for side effects that affect the lungs may also be recommended.

How Does It Work?

Rheumatrex works by inhibiting an enzyme known as dihydrofolic acid reductase (also known as dihydrofolate reductase). This enzyme is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks necessary for DNA production. By inhibiting this enzyme, Rheumatrex interferes with a cell's ability to repair and replicate (copy) itself.
Although this medicine can damage healthy cells as well as unhealthy cells, it tends to target rapidly replicating cells, such as cancer cells and bone marrow cells.
It is not entirely clear how Rheumatrex works for treating rheumatoid arthritis, although it is thought that the medication may work by affecting the immune system.
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Rheumatrex Medication Information

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