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Rheumatrex Drug Interactions

Problems can occur when certain drugs interact with Rheumatrex. For example, antibiotics can change the way Rheumatrex is absorbed by the body, either increasing or decreasing the potency of Rheumatrex. If you take phenytoin, your healthcare provider may need to lower your Rheumatrex dosage and monitor you closely. To reduce your risk of interactions, tell your healthcare provider about all medications you are currently taking.

An Overview of Interactions With Rheumatrex

Rheumatrex® (methotrexate) can potentially interact with a number of other medicines. These drugs that may lead to interactions with Rheumatrex include but are not limited to:
  • Salicylates, such as:
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Bismuth subsalicylate (Pepto-Bismol®)
    • Choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
  • Theophylline (Uniphyl®, Theocron®, TheoCap®, Theo-24®, Elixophyllin®).
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Rheumatrex Medication Information

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