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Specific Drugs That React With Protopic

More Detail on Protopic Drug Interactions

The following sections explain in detail the potentially negative reactions that can occur when Protopic is combined with any of the drugs listed above.
 
Alcohol
Drinking alcohol while using Protopic may cause facial flushing, which is a sudden redness and warmth of the skin on the face and neck. The flushing is most likely to occur on the areas where you apply the medication.
 
Cyclosporine
Combining cyclosporine and Protopic may increase your blood levels of both medicines and could increase your risk for kidney problems. Because it is a skin ointment, very little Protopic is absorbed into the body with normal use. However, this drug interaction is potentially serious, so your healthcare provider may choose to monitor you more closely, or give you a different medicine rather than have you take cyclosporine while using Protopic.
 
Calcium Channel Blockers
Taking Protopic with a calcium channel blocker could increase the level of Protopic in your body. Although very little of the drug is absorbed into the body with normal use, your healthcare provider may choose to monitor you more closely if you use Protopic while taking a calcium channel blocker. This interaction is more likely to occur with diltiazem and verapamil, or when Protopic is used on large areas of the body.
 
CYP 3A4 Inhibitor Medications
The body breaks down Protopic using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Protopic with one of these drugs may increase the level of Protopic in your body, potentially increasing your risk for side effects.
 
The risk for this interaction is generally low because very little Protopic is expected to be absorbed into the body with normal use. However, your healthcare provider may choose to monitor you more closely if you take Protopic with a CYP 3A4 inhibitor.

Protopic Medication Information

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