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Possible Reactions to Promethazine

Bothersome Promethazine Side Effects

Promethazine is a relatively "old" medication, approved before the U.S. Food and Drug Administration (FDA) required detailed side effect information in the prescribing information. Only vague information, with no specific percentages on particular side effects, was provided.
Based on this limited information, possible bothersome (but usually not dangerous) reactions to promethazine include:
  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Dizziness
  • Ringing in the ears (tinnitus)
  • Lack of coordination
  • Fatigue
  • An unusual pleasant sensation (euphoria)
  • Nervousness
  • Double vision
  • Insomnia
  • Shakiness
  • Nausea and vomiting
  • Nasal stuffiness
  • Sensitivity to the sun.

Final Thoughts

You may experience some or none of the side effects with promethazine listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be related to promethazine, your healthcare provider will be able to diagnose and treat the problem.
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