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More Instructions on Promethazine

When and How to Take This Medication

Some general considerations for those taking promethazine include the following:
  • Promethazine comes in tablet, rectal suppository, syrup, and injectable form. It is usually taken one to three times daily.
  • You can take this medicine with or without food.
  • Great care should be taken if promethazine is injected intravenously, as improper administration can cause severe tissue damage, including gangrene. In some cases, amputations have resulted.
Promethazine should not be given by "IV push" (when the medication is injected with a syringe rapidly into the IV line rather than dripped slowly into it). Injection directly into a muscle is the preferred way to inject this drug in most situations.
  • For the medication to work properly, it must be taken as prescribed.

Dosing Information

The dose of promethazine your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • Your age and weight (for children)
  • Other medications you may be taking
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Promethazine Dosage for more information.)

Drug Interactions

Promethazine can potentially interact with a number of other medications (see Drug Interactions With Promethazine).
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Promethazine HCL Medication Information

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