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How Promethazine Works and What to Tell Your Doctor

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking promethazine if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Promethazine to learn more, including information on who should not take the drug.)
 

How Does Promethazine Work?

Promethazine has several different effects in the body and the brain. Many of these effects are likely due to its antihistamine activity, since the drug works by blocking histamine receptors.
 
Promethazine also belongs to a group of medications known as phenothiazines. Although phenothiazines are usually used as antipsychotic medications, promethazine has little dopamine-blocking activity. This makes it a weak antipsychotic medication, and it is not used for this purpose.
 
This medicine also blocks acetylcholine receptors, which is probably why it helps to alleviate nausea and motion sickness.
 
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