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Promethazine Oral

Promethazine hydrochloride (Phenergan®) is a drug approved for the treatment of nausea and vomiting, motion sickness, allergies, and various other conditions. It is a sedating antihistamine that belongs to a group of medications known as phenothiazines.
 
There are several different forms of promethazine: oral tablets and syrup, rectal suppositories, and an injection. The prescription medication is generally taken one to three times a day, depending on your age and the specific condition being treated. Oral forms of promethazine should be stored at room temperature, while the suppositories should be kept in the refrigerator.
 
Promethazine has several different effects in the body and the brain. Many of these effects are most likely due to its antihistamine activity, since it works by blocking histamine receptors.
 
Promethazine also belongs to a group of medications known as phenothiazines. Although phenothiazines are usually used as antipsychotic medications, promethazine has little dopamine-blocking activity, and it is not used for this purpose. This medicine also blocks acetylcholine receptors, which is probably why it helps to alleviate nausea and motion sickness.
 
(Click Promethazine to learn more about the uses of this medication, suggestions on when and how to take it, and what side effects may occur.)
 
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