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What You Need to Know About Taking Promethazine

Promethazine Dosing for Nausea and Vomiting

A typical recommendation for treating nausea and vomiting in adults is 12.5 to 25 mg (for all forms of promethazine) every four to six hours as needed. For children, the healthcare provider will base the dosage on your child's weight, typically around 0.5 mg per pound, given every four to six hours as needed.
It should be noted that promethazine (and other nausea and vomiting medications) should not be given to children or adolescents if the cause of the vomiting is unknown.

Dosage of Promethazine for Sedation

Typically, a promethazine dosage of 12.5 to 25 mg (any form) will produce sedation in children. Adults, however, usually require a higher amount (25 to 50 mg of any form).

General Information on Your Promethazine Dose

Some considerations for people taking promethazine include the following:
  • It is important to note that promethazine should not be used in children under the age of two, due to the risk of life-threatening breathing problems.
  • This medication comes in tablet, rectal suppository, syrup, and injectable form. It is usually taken one to three times daily.
  • You can take a dose of promethazine with or without food.
  • Great care should be taken if this drug is injected intravenously, as improper administration can cause severe tissue damage, including gangrene. In some cases, amputations have resulted.
Promethazine should not be given by "IV push" (when the medication is injection with a syringe rapidly into the IV line rather than dripped slowly into it). Injection directly into a muscle is the preferred way to give the medicine in most situations.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or promethazine dosing in general, please talk with your doctor, nurse, or pharmacist.
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