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Other Medicines That React With Promethazine

Monoamine Oxidase Inhibitors (MAOIs)
Combining promethazine with an MAOI may increase the risk of side effects, such as drowsiness or involuntary muscle movements. Check with your healthcare provider before taking these medicines together.
Other Medications That Cause Drowsiness
Check with your healthcare provider before combining promethazine with any other medication that also causes drowsiness, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
Also, the dosage of opioids (such as morphine) can usually be reduced significantly, often by as much as 25 to 50 percent, when combined with promethazine. Similarly, the dosage of barbiturates should be reduced by approximately 50 percent when combined with promethazine.
Both pramlintide and anticholinergic medications (like promethazine) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these drugs.

Final Thoughts on Drug Interactions With Promethazine

Not all interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific promethazine drug interactions that may apply to you.
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