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Drugs That Interfere With Promethazine

Promethazine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when promethazine is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking promethazine, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
 
Acetylcholinesterase Inhibitor Medications
Taking promethazine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these drugs to prevent interactions from occurring. Check with your healthcare provider before combining these medications.
 
Anticholinergic Drugs
Combining an anticholinergic medication with promethazine (which also has anticholinergic properties) can increase your risk of promethazine side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine. Check with your healthcare provider before taking these medications together.
 
CYP 2B6 and 2D6 Inhibitors
Promethazine is metabolized by specific liver enzymes known as CYP 2D6 and CYP 2B6. Certain medications, known as CYP 2D6 or 2B6 inhibitors, slow down the activity of this enzyme, causing an increase in the level of promethazine in the blood. This could lead to serious side effects. Check with your healthcare provider before combining such medications.
 
Epinephrine
One of the possible side effects of promethazine is low blood pressure (hypotension). Epinephrine should not be used to treat low blood pressure in this case, since promethazine interferes with the ability of epinephrine to increase blood pressure. Alternatives to epinephrine should be used in such situations.
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