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Common Reactions to Mupirocin

Common Side Effects

Mupirocin has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people using the drug were carefully documented. There are three different types of mupirocin products: skin cream, skin ointment, and nasal ointment. Each of these products seems likely to cause slightly different side effects.
In studies, the most common side effect of mupirocin skin ointment included:
  • Burning, stinging, or pain -- in up to 1.5 percent of people
  • Itching -- up to 1 percent.
The most common side effects seen with the skin cream included:
  • Nausea -- in up to 4.9 percent of people
  • Headache -- up to 3.6 percent
  • Burning -- up to 3.6 percent
  • Itching -- up to 2.4 percent
  • Headache -- up to 1.7 percent
  • Rash -- up to 1.1 percent.
The most common side effects of mupirocin nasal ointment included:
  • Headache -- in up to 9 percent of people
  • Stuffy or runny nose -- up to 6 percent
  • Respiratory tract problems, including upper respiratory tract infections such as the common cold -- up to 5 percent
  • Sore throat -- up to 4 percent
  • Taste changes -- up to 3 percent
  • Burning or stinging -- up to 2 percent
  • Cough -- up to 2 percent
  • Itching -- up to 1 percent.

Final Thoughts

You may experience some or none of the mupirocin side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be related to mupirocin, your healthcare provider will be able to diagnose and treat the problem.
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