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Mupirocin Overdose

While it might be possible to overdose on mupirocin, the exact effects are unknown. People with kidney disease could be susceptible to an inactive ingredient in mupirocin. Children and pets could experience problems, being more likely to take the drug by mouth, which is not how it is meant to be used. If an overdose occurs, treatment would likely involve supportive and symptomatic care.

Can You Use Too Much Mupirocin?

Mupirocin (Bactroban®) is a prescription antibiotic that is applied to the skin or into the nose, depending on the particular formulation. Although this drug is apparently not particularly toxic, it is unclear what to expect in the case of an overdose.
The specific effects of a mupirocin overdose would likely vary, depending on a number of factors, including the dosage, how it was taken (applied to the skin or nose, or taken by mouth), and whether it was taken with any other medications or substances.
Seek immediate medical attention if you or someone else may have intentionally or accidentally overdosed on mupirocin.

Effects of an Overdose

In studies, large doses of mupirocin given by mouth or even by IV did not cause problems. As a result, applying too much mupirocin is thought to be unlikely to cause serious problems. Mupirocin skin ointment contains polyethylene glycol, which could cause problems in the case of an overdose in rare cases.
In almost all situations, however, applying too much skin ointment is unlikely to cause problems due to polyethylene glycol toxicity. However, if a significant amount is absorbed, which might happen with severe burns or large open wounds, polyethylene toxicity could result, especially in people with kidney problems.
In addition, accidentally taking a mupirocin product by mouth, which might happen with a young child or a pet, could cause problems due to the inactive ingredients of the medication, which vary from formulation to formulation, since the products are not designed to be taken by mouth.
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Mupirocin Drug Information

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