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Drug Interactions With Metronidazole Gel

Combining certain products with metronidazole gel may result in an increased risk for side effects, such as bleeding, hallucinations, or other problems. Alcohol, amprenavir oral solution, and lithium are some of the substances that can cause drug interactions with metronidazole gel. Check with your healthcare provider before using any other medicine with this product.

An Overview of Metronidazole Gel Interactions

Metronidazole gel (Metrogel®) may react with a few other medications. Some of the drugs that may interact with metronidazole gel include but are not limited to:
 
 

More Detail on Drug Interactions With Metronidazole Gel

The following sections explain in detail the potentially negative interactions that can occur when metronidazole gel is combined with any of the drugs listed above.
 
Alcohol
The standard recommendation is that people taking metronidazole products, including metronidazole gel, not drink alcohol. However, this type of interaction is probably unlikely to occur when metronidazole is applied to the skin (such as with metronidazole gel), although this is not known for sure. In addition, there is some uncertainty about the validity of this interaction (see Metronidazole and Alcohol).
 
Amprenavir
Combining metronidazole gel with amprenavir oral solution (but not the other forms of amprenavir) can interact dangerously with metronidazole (the active ingredient in metronidazole gel). It is unclear whether this interaction applies to the skin formulations of metronidazole (such as metronidazole gel), as only a small amount of the medication is absorbed from the skin into the bloodstream. Check with your healthcare provider before using these medications together.

Metronidazole Gel Information

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