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Promethazine has been licensed to treat nausea, motion sickness, and various other conditions. It is available by prescription only and comes in tablet, rectal suppository, syrup, and injectable form. By blocking histamine and acetylcholine receptors, the drug causes several different effects in the body and brain. Most people have no problems with it, but side effects can include dry mouth, drowsiness, and confusion.
- Dry mouth.