Skin Home > More Medicines That Interfere With Diclofenac Gel

Taking diclofenac gel and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
"Blood Thinners" and Other Similar Drugs
Combining diclofenac gel with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine diclofenac gel with such medications without your healthcare provider's approval and supervision.
Diclofenac gel may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
Probenecid may increase the level of diclofenac gel in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
Skin Products
It is best to avoid using other skin products on the same area as diclofenac gel. It is not known how such products might affect diclofenac gel.
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with diclofenac gel may increase the risk of bleeding. Check with your healthcare provider before taking diclofenac gel with an SSRI or SNRI.
Herbal and Nutritional Supplements
Several herbal and nutritional supplements can also interact with diclofenac gel and may increase the risk of bleeding. If you are taking any natural or herbal supplements, discuss this with your healthcare provider before starting diclofenac gel therapy.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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