Skin Home > Clobex

If you have eczema, scalp psoriasis, or other skin conditions, your healthcare provider may recommend treatment with Clobex. This prescription medicine comes in three forms and is typically used once or twice a day. As a steroid, it works by decreasing inflammation and suppressing an overactive immune system. Common side effects include a burning sensation, spider veins, and weakening of the skin.

What Is Clobex?

Clobex® (clobetasol propionate) is a prescription skin medication that comes in the form of a lotion, shampoo, and spray. It belongs to a group of medications known as topical steroids.
The shampoo is approved to treat scalp psoriasis. The spray is approved to treat plaque psoriasis. The lotion is approved to treat inflammation and itching due to a wide variety of skin conditions, such as eczema, psoriasis, dermatitis, and allergic reactions.
(Click Clobex Uses for more information on this topic, including possible off-label uses.)

Who Makes Clobex?

Clobex shampoo and lotion are made by DPT Laboratories, Ltd., for Galderma Laboratories, L.P. Clobex spray is made by CPL for Galderma Laboratories, L.P.

How Does It Work?

Clobex is part of a group of medications known as glucocorticoids. Glucocorticoids are a type of corticosteroid, or "steroid" for short. Although glucocorticoids have numerous effects in the body, they are used mostly for their anti-inflammatory or immune-suppressing properties. Clobex works for most conditions by decreasing inflammation or suppressing an overactive immune system.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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