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Istodax Risks

Specific Precautions and Warnings With Istodax

Some warnings and precautions to be aware of prior to receiving this medication include the following:
 
  • Istodax can decrease the number of red blood cells, white blood cells, and platelets in your blood. This could lead to serious problems, such as:
 
    • Anemia from low red blood cells, which could cause extreme fatigue, pale skin, and shortness of breath
    • An increased risk for infection from low white blood cells
    • Abnormal bruising or bleeding from low platelets.
 
Your healthcare provider will monitor your blood cell counts throughout treatment. Be sure to tell him or her if you experience signs of anemia, believe you may have an infection, or have any unusual bruising or bleeding.
 
  • You may be at risk for life-threatening infections, including pneumonia and blood infections, during treatment and for up to 30 days after treatment ends. Some people died from infections during Istodax treatment. Your risk for life-threatening infections is higher if you have received intensive chemotherapy in the past. Tell your healthcare provider right away if you develop signs of an infection, such as:
 
    • Fever
    • Aches and pains
    • Cough
    • Shortness of breath
    • Sore throat.
 
  • Istodax has been reported to cause changes in the normal rhythm of the heart. People who have heart disease, a heart rhythm problem known as QT prolongation, or take QT-prolonging medicines (see Istodax Drug Interactions) may have a higher risk for such problems. Your healthcare provider may choose to check your electrolytes, such as potassium and magnesium, with a blood test and your heart with an electrocardiogram (ECG) before you begin treatment. Tell your healthcare provider if you experience problems such as:
 
    • An abnormal heartbeat
    • Dizziness
    • Fainting
    • Chest pain
    • Shortness of breath during treatment.
 
  • There have been reports of tumor lysis syndrome (the development of metabolic and electrolyte disturbances caused by the breakdown of tumor cells in people undergoing cancer treatment) in people using this medicine. Tumor lysis syndrome can lead to life-threatening complications. People who have many tumors, or who have more advanced cancer, are at a higher risk for tumor lysis syndrome and should be monitored closely.
 
 
  • Istodax is a pregnancy Category D medication, which means it may harm an unborn child if used during pregnancy (see Istodax and Pregnancy).
 
  • It is unknown whether Istodax passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Istodax and Breastfeeding).
 
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Istodax Medication Information

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