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Istodax Side Effects

In a majority of cases, people who receive Istodax will develop some type of side effect. Clinical trials have shown that some of the most commonly reported reactions include nausea, fatigue, and changes in heart rhythm. There are also potentially serious side effects of Istodax, such as chest pain or severe diarrhea, which require immediate medical treatment.

An Introduction to Istodax Side Effects

Just like any medicine, Istodax® (romidepsin) can cause side effects and, like other chemotherapy medicines, the reactions can be significant. Although not everyone who uses this drug will have problems, most people will experience some type of side effect. Talk to your healthcare provider about ways to prevent or lessen adverse reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Istodax. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Istodax

Istodax has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Istodax side effects included:
  • Nausea -- in up to 86 percent of people
  • Weakness and fatigue -- up to 77 percent
  • Anemia (low red blood cell counts) -- up to 72 percent
  • Low platelet counts -- up to 72 percent
  • Low white blood cell counts -- up to 66 percent
  • Heart rhythm changes (arrhythmias) -- up to 63 percent
  • Infections -- up to 54 percent
  • Decreased appetite -- up to 54 percent
  • Vomiting -- up to 52 percent
  • Low levels of calcium in the blood (hypocalcemia) -- up to 52 percent.
Other common reactions, occurring in 10 percent to 51 percent of people, included:
  • High blood sugar levels (hyperglycemia)
  • A metallic or bad taste in the mouth
  • Low levels of albumin in the blood
  • Constipation
  • Headache
  • Fever
  • Itching
  • Diarrhea
  • Redness, itching, or swelling of the skin
  • Cough
  • Shortness of breath
  • Low blood pressure
  • Abdominal (stomach) pain
  • Inflammation or sores in the mouth
  • Chills
  • Weight loss
  • A fast heart rate (tachycardia)
  • Electrolyte changes, such as low sodium and potassium levels and low or high magnesium levels
  • Increases in certain liver enzymes
  • Swelling of the arms, hands, legs, ankles, or feet.
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Istodax Medication Information

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