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More Info on IncobotulinumtoxinA Indications

Using IncobotulinumtoxinA for Blepharospasm

Sometimes, abnormal muscle spasms or contractions can affect the eye, causing eyelid twitches (known as blepharospasm). IncobotulinumtoxinA is approved for treating these eyelid twitches in adults who have been previously treated with Botox. This restriction is due to the fact that the studies of incobotulinumtoxinA for blepharospasm involved people who had previously been treated with and responded well to Botox.
 

How Does It Work?

IncobotulinumtoxinA contains a toxin produced by Clostridium botulinum bacteria. The drug works by decreasing nerve signals that are sent to muscles, which causes the muscles to relax. IncobotulinumtoxinA enters nerve cells and inhibits the release of acetylcholine, a chemical that transmits signals from nerve to nerve. The actions of the drug are not permanent, and the muscle will eventually recover and return to its previous state.
 

Can Children Use IncobotulinumtoxinA?

This drug is not approved for use in individuals under the age of 18 years old. If you think your child may benefit from these injections, make sure to discuss the possible risks with your child's healthcare provider.
 

Is IncobotulinumtoxinA Used for Off-Label Reasons?

On occasion, a healthcare provider may recommend this product for something other than the conditions discussed in this article. This is called an "off-label" use. At this time, off-label incobotulinumtoxinA uses include treating the following conditions:
 
  • Severe underarm sweating
  • Misaligned eyes, such as crossed eyes (known medically as strabismus)
  • Achalasia (a condition involving difficulty swallowing)
  • Drooling
  • Muscle spasms in children with cerebral palsy
  • Neurogenic bladder (bladder disorders caused by nerve problems)
  • Migraine headaches.
 
Also, using incobotulinumtoxinA for other cosmetic uses (other than for frown lines between the eyebrows) would be considered off-label uses.
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