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Common Reactions to IncobotulinumtoxinA

Common Side Effects

IncobotulinumtoxinA has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given incobotulinumtoxinA were documented and compared to the side effects that occurred in a similar group of people given a placebo (an injection that did not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group receiving the placebo.
 
In studies of incobotulinumtoxinA for cosmetic use (to improve the appearance of lines between the eyebrows), the only common side effect was headaches, which occurred in 5.4 percent of people who received incobotulinumtoxinA, compared to 2.2 percent of people who received the placebo. All other side effects occurred in less than 1 percent of people.
 
In studies of incobotulinumtoxinA for treating cervical dystonia (a condition involving muscle spasms of the head and neck), the most common side effects included:
 
  • Difficulty swallowing -- in up to 18 percent of people
  • Neck pain -- up to 15 percent
  • Any infection -- up to 13 percent
  • Muscle weakness -- up to 11 percent
  • Muscle pain -- up to 4 percent
  • Pain at the injection site -- up to 4 percent.
 
In studies of incobotulinumtoxinA for blepharospasm (eyelid spasms), the most common side effects included:
 
  • Any type of infection -- in up to 20 percent of people
  • Droopy eyelids -- up to 19 percent
  • Dry eyes -- up to 16 percent
  • Dry mouth -- up to 16 percent
  • Vision problems -- up to 12 percent
  • Diarrhea -- up to 8 percent
  • Headache -- up to 7 percent
  • Shortness of breath -- up to 5 percent.
 
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IncobotulinumtoxinA Drug Information

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