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Imiquimod Dosage

If your healthcare provider recommends treatment with imiquimod, the specific dosing guidelines will depend on which product you are using, the skin condition being treated, and various other factors. He or she will review specific instructions on how much of this medicine to use, where to apply it, and how long to continue treatment. Make sure to protect your skin from the sun while using imiquimod.

An Introduction to Your Dosage of Imiquimod

The dose of imiquimod (Aldara®, Zyclara®) your healthcare provider recommends will depend on various factors, such as:
  • Which product is used
  • The condition being treated
  • Whether you develop severe skin reactions to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Imiquimod Dosing Guidelines for Actinic Keratosis

For Aldara (and generic versions of Aldara):
  • The standard recommended Aldara (imiquimod 5%) dosage for actinic keratosis treatment is one packet applied to the treatment area twice a week before bedtime for 16 weeks. A "treatment area" is a single area of about 25 square centimeters (an area of about 2 inches by 2 inches) on the face, scalp, or one cheek. If you have more skin to treat, this should usually be done in separate treatment cycles. Apply the cream at bedtime, leave it on for about eight hours, and then wash it off.
For Zyclara:
  • The standard recommended Zyclara dosage for actinic keratosis treatment is an adequate amount of the cream (enough to cover the entire treatment area, or up to two packets per dose or two pumps per dose) once a day at bedtime for two weeks. After two weeks, a two-week-break is needed. Then another two weeks of treatment is usually recommended.
  • Zyclara 2.5% and Zyclara 3.75% cream are both approved for this use.
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Imiquimod Cream Information

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