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Drug Combinations With Hydroxyzine to Avoid

Hydroxyzine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when hydroxyzine is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcoholic beverages while you are taking hydroxyzine, as undesirable or even potentially dangerous side effects (such as excessive drowsiness, dizziness, or confusion) may result.
 
Acetylcholinesterase Inhibitors
Taking hydroxyzine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent drug interactions from occurring. Check with your healthcare provider before combining these medications.
 
Anticholinergic Drugs
Combining an anticholinergic medication with hydroxyzine (which has anticholinergic properties) can increase your risk of hydroxyzine side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine. Check with your healthcare provider before taking these medications together.
 
Other Medications That Cause Drowsiness
Check with your healthcare provider before combining hydroxyzine with any other medication that also causes drowsiness, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
 
Also, the dosage of opioids (such as morphine) can usually be reduced significantly, often by as much as 50 percent, when combined with hydroxyzine because hydroxyzine improves the effectiveness of opioids.
 
Phenothiazines
Hydroxyzine may increase the risk of a dangerous irregular heart rhythm (arrhythmia) due to a phenothiazine medication. In addition, combining these two medications increases the risk of excessive drowsiness.
Drink Less Alcohol

Hydroxyzine Drug Information

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