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Reported Reactions to Fluocinonide

Reported Side Effects

Fluocinonide 0.05% products (Lidex) are older medications. As is common with older medications, only vague side effect information is provided in the prescribing information.
Based on this limited information, the most common fluocinonide side effects (in decreasing order) include:
  • Burning
  • Irritation
  • Itching
  • Dryness
  • Irritation or infection of hair follicles of the skin (folliculitis)
  • Increased sweating
  • Acne
  • Loss of skin pigment (lightening of the skin)
  • Rash around the mouth
  • Allergic skin rash
  • Whitening and softening of the skin
  • Infection
  • Weakening and thinning of the skin
  • Stretch marks
  • "Prickly heat" sweat rash (miliaria).
Fluocinonide 0.1% cream (Vanos) is a newer medication, with more detailed side effect information available. Vanos has been studied thoroughly in clinical trials. In these studies, one group of people received Vanos, while another group was given a placebo (a cream with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In clinical trials, the most common Vanos side effects included:
  • Headache -- up to 4 percent of people
  • Burning at the application site -- up to 2.3 percent
  • Nasal congestion -- up to 1.4 percent.
In general, adverse reactions are more common when a dressing (such as a bandage) is used to cover the medication. Do not use a dressing unless your healthcare provider specifically recommends that you do so.

Fluocinonide Drug Information

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