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Drug Interactions With Diclofenac Gel

A number of medications may cause diclofenac gel drug interactions, including anticoagulants, ACE inhibitors, and certain diuretics. Although diclofenac is a skin gel, it can still interact with other medicines because it is absorbed into the bloodstream. Drug interactions with this product may lead to an increased risk for side effects, reduce the effectiveness of the medications, or cause other potentially dangerous problems.

An Overview of Diclofenac Gel Interactions

Even though diclofenac gel (Solaraze® Gel, Voltaren® Gel) is applied to the skin, it can potentially interact with several other medications (since some of the medication is absorbed into the bloodstream). Some of the medicines that may lead to drug interactions with diclofenac gel include:
 
  • Angiotensin-converting enzyme (ACE) inhibitors, including:

 

 

  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with diclofenac gel and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Top Foods to Fight Inflammation

Diclofenac Gel Drug Information

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