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More Info on Denileukin Diftitox Indications

How Does This Medication Work?

Denileukin diftitox is made by genetically combining protein from the diphtheria toxin with interleukin-2 (IL-2), a naturally occurring protein of the immune system. Interleukin-2 binds to lymphocytes (white blood cells) that have IL-2 receptors on their surface, including cutaneous T-cell lymphoma cancer cells. After binding to the cancer cells, the diphtheria toxin portion of denileukin diftitox causes the cancer cells to die.

Can Children Use Denileukin Diftitox?

Denileukin diftitox is not approved for use in children, as it has not been adequately studied in this age group (usually defined as individuals younger than 18 years of age). Talk to your child's healthcare provider about the risks and benefits of using this medication in a person younger than age 18.

Is It Used in Older Adults?

Clinical studies of the drug did not include enough older adults to determine if they responded to the medicine in the same way as younger age groups. Although older adults can use this medicine, they may be more sensitive to denileukin diftitox side effects and may need to be monitored closely during treatment.

Is Denileukin Diftitox Used for Off-Label Reasons?

On occasion, a healthcare provider may recommend this medication for treating something other than cutaneous T-cell lymphoma. This is called an "off-label" use. Denileukin diftitox may be used off-label to treat other types of T-cell lymphoma or chronic lymphoid leukemia.
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Denileukin Diftitox Drug Information

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