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Denileukin Diftitox Side Effects

A majority of people receiving denileukin diftitox will experience some type of side effect during treatment. Clinical studies have shown that some of the most commonly reported problems include fever, vomiting, and a loss of appetite. Significant reactions also can occur that may lead to dangerous and even life-threatening complications, such as chest pain, difficulty breathing, and thyroid problems.

An Introduction to Side Effects With Denileukin Diftitox

Just like any chemotherapy medicine, denileukin diftitox (Ontak®) can cause side effects, some of which can be quite significant. Although not everyone who receives this drug will have problems, most people will experience some type of side effect. Talk to your healthcare provider about ways to prevent or lessen adverse reactions during treatment.
 
(This article covers many, but not all, of the possible side effects with denileukin diftitox. Your healthcare provider can discuss a more complete list with you.)
 

Serious Denileukin Diftitox Side Effects

Some side effects of denileukin diftitox are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Signs of an allergic reaction or an infusion reaction (a reaction that happens while receiving or soon after your dose), such as:
 
    • Rash
    • Fever
    • Chills
    • Difficulty breathing or swallowing
    • Chest pain
    • Fast heartbeat
    • Hives
    • Dizziness or fainting
    • Swelling of the mouth, tongue, face, lips, or throat
    • Sweating
 
  • Signs of thyroid problems, such as:
 
 
  • Vision problems, including loss of color vision
  • Low blood pressure (hypotension), which could cause dizziness or fainting, especially when standing up
  • Swelling of the arms, legs, ankles, or feet
  • Unexplained rapid weight gain
  • Severe or persistent vomiting or diarrhea.
 
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Denileukin Diftitox Drug Information

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