What You Need to Know About Denileukin Diftitox
Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to receiving this medication if you have:
- Been told you have low levels of albumin (a protein found in the body)
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Ontak and Pregnancy)
- Breastfeeding (see Ontak and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Denileukin Diftitox to learn more, including information on who should not receive the drug.)
How Does Denileukin Diftitox Work?Denileukin diftitox is made by genetically combining protein from the diphtheria toxin with interleukin-2 (IL-2), a naturally occurring protein of the immune system. Interleukin-2 binds to lymphocytes (white blood cells) that have IL-2 receptors on their surface, including cutaneous T-cell lymphoma cancer cells. After binding to the cancer cells, the diphtheria toxin portion of denileukin diftitox causes the cancer cells to die.