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Denileukin Diftitox Dosage

Your healthcare provider will take your weight into consideration when calculating your dosage of denileukin diftitox. This chemotherapy drug is administered by your healthcare provider in a healthcare setting. It is injected slowly into a vein over 30 to 60 minutes. It is given every day for five days, once every three weeks. This treatment regimen will be repeated for eight cycles.

An Introduction to Your Dosage of Denileukin Diftitox

The dose of denileukin diftitox (Ontak®) your healthcare provider recommends will vary, based on a number of factors, including:
  • Your weight
  • Your healthcare provider's impression of how much medicine you may need to treat your condition.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Denileukin Diftitox Dosing Guidelines

The usual recommended dosage of denileukin diftitox for treating cutaneous T-cell lymphoma is 9 or 18 micrograms (mcg) per kg body weight (about 4.09 or 8.18 mcg per lb) given once a day for five days in a row. This five-day treatment is normally given every 21 days for eight cycles, as long as potentially serious side effects do not occur.
You will be given acetaminophen (Tylenol® and others) and an antihistamine, such as diphenhydramine (Benadryl® and others), before each dose. These medicines are given to reduce your risk of developing a potentially serious reaction to the denileukin diftitox infusion.
Your healthcare provider will check your blood levels of albumin (a protein found in the body) before each dose. If the levels are too low, your treatment will be temporarily interrupted until the levels return to normal.
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Denileukin Diftitox Drug Information

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