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Drug Interactions With Dacarbazine

More Detail on Drug Interactions With Dacarbazine

The following sections explain in detail the potentially negative reactions that can occur when dacarbazine is combined with any of the drugs listed above.
Amphotericin B
Combining amphotericin B with chemotherapy medicines, including dacarbazine, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Biologic and Immunologic Medications
Using dacarbazine in combination with certain biologic and immunologic medications could increase your risk for potentially serious side effects, including low blood cell counts and infections. Dacarbazine should not be used in combination with some of these medications, while other combinations require careful monitoring. Talk to your healthcare provider about this potential reaction if you are taking a biologic or immunologic medicine during dacarbazine treatment.
Taking clozapine and dacarbazine together may increase the risk for dangerously low white blood cells, and potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
CYP 1A2 Inducer Medications
The liver breaks down dacarbazine using enzymes known as CYP 1A2 enzymes, and some medications known as CYP 1A2 inducers can increase the activity of these enzymes. Thus, combining dacarbazine with one of these drugs may decrease the level of dacarbazine in your body, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you use dacarbazine with a CYP 1A2 inducer.
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