You should talk with your healthcare provider prior to receiving this medication if you have:
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, such as kidney failure (renal failure)
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see DTIC-Dome and Pregnancy)
- Breastfeeding (see DTIC-Dome and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Dacarbazine to learn more, including information on who should not use the drug.)
It is not entirely known how dacarbazine works to treat cancer. It is classified as an alkylating agent. Alkylating agents are medications that transfer a piece of their structure, called an alkyl group, to DNA. This causes the strands of DNA to bond to each other and become linked (known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to replicate.
Dacarbazine may also work by incorporating itself into DNA and interfering with the ability of the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, dacarbazine may prevent cancer cells from growing and multiplying.