The recommended dacarbazine dosage will be different for each person, depending on his or her weight, the reason the medicine is being used, and a number of other factors. This prescription drug comes as an injection that is given into a vein (intravenously, or by IV). Although dosing regimens will vary, this medicine is usually given once daily for 5 to 10 days, followed by a break.
The dosage of dacarbazine (DTIC-Dome®) your healthcare provider recommends will vary, depending on a number of factors, including:
- Your weight and possibly height
- The reason you are using it
- How you respond to and tolerate the medication
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The usual recommended dose of dacarbazine for treating melanoma (skin cancer) is 2 to 4.5 mg per kg body weight (about 0.09 to 2.04 mg per lb) once a day for 10 days. This dose may be repeated every four weeks.
Alternately, your healthcare provider may recommend a dosage based on your body surface area, which is normally calculated using your height and weight. Doses based on body surface area are expressed as milligram per meter squared (mg per m2). The usual recommended dose of dacarbazine based on body surface area is 250 mg per m2 daily for 5 days. This dose may be repeated every three weeks.
The usual recommended dosage of dacarbazine for treating Hodgkin's disease is 150 mg per m2 daily for 5 days. This dose may be repeated every four weeks.
An alternate dose that may be recommended for the treatment of Hodgkin's disease is 375 mg per m2 given every 15 days. When used to treat Hodgkin's lymphoma, dacarbazine is used in combination with other medicines, regardless of the amount used.