Clobex and Pregnancy
In studies of pregnant animals, steroids such as Clobex (clobetasol propionate) were shown to cause problems such as poor fetal growth. It is unknown if these problems would also occur in humans, but it is probably best to avoid using this medicine over a large area for extended periods. Your healthcare provider may also recommend trying a less potent steroid first.
Clobex® (clobetasol propionate) is a prescription topical steroid approved for treating various skin conditions. Based on information currently available, it is unclear if the drug is safe for use during pregnancy. As with most medications, it should be used only if necessary, at the lowest effective dose, and for the shortest time necessary during pregnancy.
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Clobex is a steroid. Animal studies have shown that steroids may increase the risk of birth defects and may cause other problems, such as poor fetal growth or even stillbirth. Similar problems might also occur in humans, although the risk is probably smaller with topical steroids like Clobex, which are applied to the skin.
While short-term use of Clobex (a few days) applied to a small area of the body is probably not likely to cause problems (although this is not known for sure), extended use or use over a large area of the body should probably be avoided during pregnancy if possible. In addition, Clobex is an extremely potent steroid. It is probably better to try a less potent steroid first.