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What Are the Long-Term Effects of Clobetasol Propionate?

Clobetasol Propionate and HPA Suppression

Using steroids, including clobetasol propionate, for a long time can cause a different set of side effects, sometimes known as adrenal suppression, HPA suppression, or Cushing's syndrome. These adverse reactions are most likely to be seen in people who use the medication over a large area of the body for a long time (more than two weeks). Some symptoms of this complication may include:
  • Suppression of the immune system, perhaps leading to infections or other problems
  • Weight gain
  • Bulging eyes
  • Fluid retention
  • Osteoporosis
  • Loss of muscle
  • Fat deposits on the face and back, causing a round face and a fatty hump on the back of the neck
  • Diabetes
  • Cataracts
  • Stunted growth (in children).
Clobetasol propionate is a highly potent steroid and is more likely to cause these side effects, compared to less potent steroids. This is why this medication is recommended only for short-term use (normally two weeks or less).

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using clobetasol propionate or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.

Clobetasol Propionate Drug Information

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